Transient Antibody Expression Explained

A practical guide to faster, more reliable recombinant antibody production.

Transient expression is the fastest way to produce multiple antibody variants during early discovery and optimization. This whitepaper breaks down the workflow, highlights the critical yield drivers, and helps you choose the right expression strategy at each stage.

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This White Paper includes:

Part A: Principles of Transient Antibody Production
  • Recombinant Antibodies and the Role of Transient Expression
  • Key Steps in the Transient Production Workflow
  • Transient production workflow
  • Different approaches in Recombinant antibody production
  • Differences between stable & transient production
  • Choosing the Right Approach

Part B: Choosing the Right Expression Strategy Across Antibody Development Stages

  • Early Discovery / Variant Screening
  • AI-Driven Optimization (Mid-Pipeline)
  • Lead Selection
  • Late-Stage Discovery
  • Expression strategy quick-Check

Part C: In-House vs. Outsourced Transient Antibody

  • Production: Making the Strategic Choice
  • When In-House Production Makes Sense
  • When Outsourcing Brings Clear Advantages
  • Key Risks and Challenges for Internal Scaling
  • Quick Comparison: In-House vs. Outsourced
  • 5 questions to ask yourself before outsourcing
  • Questions to Ask Any Provider

The Authors

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Carla NARRO MERCADO, MSc

Scientific Writer

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Claire PERROT, Ing

Scientific Writer

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Thomas MEYER, Phd

Scientific Writer