--- title: Case report Affinity Maturation --- [![logo_blanc-300](https://go.proteogenix.science/hs-fs/hubfs/logo_blanc-300.png?width=235&height=140&name=logo_blanc-300.png)](https://www.proteogenix.science) # Accelerating neurology diagnostic development with AI-driven Antibody Affinity Maturation ## **A pratical example of computational guidance with experimental confirmation** Discover how a pharma team achieved up to a **20-fold affinity improvement** for a mouse antibody targeting a human antigen—using paratope–epitope mapping, AI-guided variant design, and rapid wet-lab validation to reach reliable diagnostic performance. ![booklet_no_claim](https://go.proteogenix.science/hs-fs/hubfs/booklet_no_claim.png?width=2000&name=booklet_no_claim.png) ### Complete the form and receive free case report! # This Case Report includes: - A detailed step-by-step maturation workflow combining IA  - Comprehensive results highlighting measurable affinity gains - Clear decision logic and key checkpoints to manage risk - Validation insights you can apply to your own diagnostic programs   --- --- --- --- [![ft_logo](https://go.proteogenix.science/hubfs/ft_logo.svg)](https://www.proteogenix.science/) © 2026 ProteoGenix | All rights reserved | [Legal notices](https://www.proteogenix.science/legal-notices/)